AHCC is an acetylated alpha-glucan-rich compound made from Japanese medicinal mushrooms fermented in rice bran that, according to the company, supports normal immune function and may improve the number and functions of immune system cellshttps://qualityoflife.net/products/ahcc-kinoko-platinum?variant=806575636503¤cy=USD&gclid=EAIaIQobChMIgoXi7rS36AIVTf_jBx3UZArnEAQYASABEgKphfD_BwE
A cultured extract of hybridized medicinal mushroom mycelia (roots), AHCC® is one of the world's most researched specialty immune supplements, supported by over 30 human clinical studies. AHCC has been shown to: Maintain optimal NK cell activity.
AHCC®
AHCC® is produced by a patented process of Shiitake cell culture. AHCC®’s main active components, alpha-glucans, are small molecules easily absorbed by the organism. AHCC® is Japan’s top-selling immune support ingredient, its properties have been described in more than 60 scientific articles, including reports of more than 30 human clinical studies. AHCC® is produced…
AHCC® - VF Bioscience
AHCC® is produced by a patented process of Shiitake cell culture. ... AHCC® is Japan's top-selling immune support ingredient, its properties have been .
reviews of the product.
Nearly all of the research into AHCC has been funded by the manufacturer, which complicates the discussion of currently available results – independent research is needed to verify them.
AHCC (Amino-Up Chemical Company, Sapporo, Japan) is a proprietary, alpha glucan-rich nutraceutical ingredient prepared by culturing Shiitake and other Basidiomycetes mushrooms with rice branActive Hexose Correlated Compound
AHCC: Active Hexose Correlated Compound is a mushroom extract supplied by Quality of Life Labs. It is a mixture of polysaccharides, amino acids, lipids and minerals derived from cocultured mycelia of several species of Basidiomycete mushrooms. AHCC has been implicated to modulate immune functions and plays a protective role against infection. In a 2006 animal study, it was shown to increase NK cells, killer T-cells and macrophages — all immune-enhancing lymphocytes that regulate both innate and adaptive immune responses.20
In a 2008 double-blind, placebo-controlled, randomised human clinical trial in Japan, the 10 subjects taking 3g/day AHCC for four weeks experienced improvements in some immunity markers — specifically elevated circulating dendritic cells and clusters of differentiation and allogeneic mixed-leukocyte reaction — while no change was observed in NK cell activity and the proliferative response of T lymphocytes toward mitogen.21
In a December 2007 study to assess AHCC's safety and tolerability, 26 human subjects were given 9g AHCC/day for 14 days in a liquid format. The dosage well exceeds the normal dose, and it was well tolerated by 85 per cent of subjects, with transient adverse effects of nausea, diarrhoea and bloating.22
Of note, a 2007 study in rats found AHCC to possess both anti-inflammatory as well as prebiotic properties. Rats receiving AHCC showed greater colonic bifidobacteria counts and lower incidence of clostridia bacteria.23 Other published studies in the past two years indicate efficacy in animal models in enhancing resistance to infection after surgery, increasing innate immune response to primary influenza infection, and even enhanced immunity while in outer space.24,25,26
In all, AHCC has been the subject of more than 80 clinical trials. It is said that more than 700 hospitals and medical clinics in Japan recommend AHCC as part of an immune-maintenance regimen. It received the NutrAward in 2002 for best new product of the year at the Nutracon conference. The recognition was based on the product's scientific merit, efficacy, safety, innovation, market potential and ability to advance the industry. As a patented ingredient, AHCC can be exclusively licensed to select manufacturers.
20. Gao Y, et al. Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses. Cancer Immunol Immunother 2006 Oct;55(10):1258-66.
21. Terakawa N, et al. Immunological effect of active hexose correlated compound (AHCC) in healthy volunteers: a double-blind, placebo-controlled trial. Nutr Cancer 2008;60(5):643-51.
22. Spierings EL, et al. A phase I study of the safety of the nutritional supplement, active hexose correlated compound, AHCC, in healthy volunteers. J Nutr Sci Vitaminol (Tokyo) 2007 Dec;53(6):536-9.
23. Daddaoua A, et al. Active hexose correlated compound acts as a prebiotic and is anti-inflammatory in rats with hapten-induced colitis. J Nutr 2007 May;137(5):1222-8.
24. Aviles H, et al. Active hexose correlated compound (AHCC) enhances resistance to infection in a mouse model of surgical wound infection. Surg Infect (Larchmt) 2006 Dec;7(6):527-35.
25. Ritz BW, et al. Supplementation with active hexose correlated compound increases the innate immune response of young mice to primary influenza infection. J Nutr 2006 Nov;136(11):2868-73.
26. Aviles H, et al. Active hexose correlated compound enhances the immune function of mice in the hindlimb-unloading model of spaceflight conditions. J Appl Physiol 2004 Oct;97(4):1437-44.
Influenza virus is one of the most significant viral infections that causes substantial mortality and morbidity in older adults, children, and immune-compromised hosts [40]. The effect of AHCC® on influenza viral infection has been studied, showing the possible beneficial effect, especially through affecting NK cells [24]. Supplementing mice orally with AHCC® (1 g/kg/day) improved survival and lung integrity upon intranasal challenge with influenza virus (H1N1) [24]. The mice that received AHCC® had increased NK cell percentages and activity as measured against YAC-1 target cells, along with decreased viral titers in the lungs [24]. The former finding could be a potential mechanism responsible for the beneficial effect of AHCC® in this mouse model in that NK cells were suggested to have a role in controlling influenza viral infection by secreting cytokines and expressing cytotoxic molecules [30]. The improvement of survival with enhanced viral clearance and NK cell lytic efficiency was also found in influenza virus-infected mice which were supplemented with a low-dose AHCC® (0.1 g/kg/day) [22]. Of note, a transient deficiency of NK and T cells was found in patients with severe H1N1 influenza [41]. Given the increased NK cells in mice treated with AHCC® [24], it would be intriguing to test whether AHCC® could increase NK cells in patients with H1N1 influenza. The effect of AHCC® can be beyond H1NI influenza. The survival benefit by AHCC® supplementation was observed in mice infected with avian (bird) influenza virus H5N1 which could infect humans and poultry although its mechanism is yet to be demonstrated [15]. In fact, the mortality rate of H5N1 avian influenza is much higher than that of past influenza pandemics, reaching up to 60% [42]. The available data support the implication of NK cells in controlling influenza virus via promoting the number and function of NK cells, raising the possible consideration of exploring the clinical utility of AHCC® for influenza viral infections, including avian influenza infection, in humans.
Active Hexose-correlated Compound Down-regulates HSP27 ...
Selected references
Aviles et al. 2008. Active hexose correlated compound activates immune function to decrease bacterial load in a murine model of intramuscular infection. Am J Surg. vol. 195(4), pp. 537-45.Ito et al. 2014. Reduction of adverse effects by a mushroom product, active hexose correlated compound (AHCC) in patients with advanced cancer during chemotherapy – The significance of the levels of HHV-6 DNA in saliva as a surrogate biomarker during chemotherapy. Nut Cancer vol. 66(3), pp. 377-82.
Kim et al. 2014. Effect of active hexose correlated compound (AHCC) in alcohol-induced liver enzyme elevation. J Nutr Sci Vitaminol. vol. 60(5), pp. 348-56.
Matsui et al. 2011. Active hexose correlated compound inhibits the expression of proinflammatory biomarker iNOS in hepatocytes. Eur Surg Res. vol. 47(4), pp. 274-83.
Nogusa et al. 2009. Low dose supplementation with active hexose correlated compound improves the immune response to acute influenza infection in C57BL/6 mice. Nutr Res. vol. 29(2), pp. 139-43.
Roman et al. 2013. Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine. Nutr Res. vol. 33(1), pp. 12-17.
Takanari et al. 2015. Effects of active hexose correlated compound on the seasonal variations of immune competence in healthy subjects. J Evid Based Complementary Altern Med. vol. 20(1), pp. 28-34.
Terakawa et al. 2008. Immunological effect of active hexose correlated compound (AHCC) in healthy volunteers: a double blind, placebo-controlled trial. Nutr Cancer vol. 60(5), pp. 643-51.
Yin et al. 2010. Effects of active hexose correlated compound on frequency of CD4+ and CD8+ T cells producing interferon-gamma and/or tumor necrosis factor-alpha in healthy adults. Hum Immunol. vol. 71(12), pp. 1187-90.
Graham et al. 2017. MicroRNA signature in the chemoprevention of functionally-enriched stem and progenitor pools (FESPP) by Active Hexose Correlated Compound (AHCC). Cancer Biol Ther. vol. 18(10), pp. 765-74.
Smith et al. 2019. From bench to bedside: evaluation of AHCC supplementation to modulate the host immunity to clear high-risk human papillomavirus infections. Front. Oncol. vol. 4(173).
https://www.realmushrooms.com/polysaccharides-mushrooms-poor-quality-measurement/
On paper these products can tout high polysaccharide amounts (alpha-glucans + beta-glucans) but in reality the majority of those polysaccharides come from alpha-glucans in the form of starches and fillers. Those alpha-glucans provide no medicinal benefit.
This concept is extremely important to understand when it comes to medicinal mushroom products. It is quite concerning because many products on the market tout polysaccharide numbers yet fail to mention any beta-glucan numbers.
For example, products#2, 3, 8 and 12 in the table above are actually mycelium products that are grown on grain. They all can tout >60% polysaccharides but the polysaccharides are mainly coming from alpha-glucans in the form of grain starch and the products contain very little beta-glucans.
Beware that products grown in North America are almost always mycelium grown on grain.Isolation and comparison of α- and β-D-glucans from shiitake mushrooms (Lentinula edodes) with different biological activities
Isolated glucans exerted HMGCR inhibitory activity, but only β-(1→6) and β-(1→3),(1→6) fractions showed DPPH scavenging capacity.https://www.nammex.com/
All our mushroom extracts are from the leading supplier of organic mushroom extracts: Nammex. They have over 40 years of mushroom growing experience and were one of the first companies to bring organic medicinal mushroom extracts to North America. Their ingredients go through rigorous quality control and are tested twice for heavy metals, agricultural chemicals and microbial contamination to ensure they meet all standards for dietary supplements of this nature. All of their extract are made from certified organic mushrooms (fruiting bodies), organically grown or wildcrafted from deep within mountain regions of China.
The scientist Goro Chihara fractionated Shiitake polysaccharides and named the most active fraction lentinan, a pure beta-1-3-glucan. This compound was developed into a drug that has been utilized as a complement to traditional medical practices in Japanese oncology.
US lab-grown Shiitake is mycelium grown on grain. Analysis has shown that US Shiitake mycelium on grain has low levels of beta-glucan and very high levels of starch.
- Wasser S., Shiitake. Encyclopedia of Dietary Supplements. 2005, Marcel Dekker.
- Chihara, G., Medical Aspects of Lentinan Isolated from Lentinus edodes. Mushroom Biology and Mushroom Products, Proceedings of 1st International Conference, Hong Kong. 1993 Ed. S.T. Chang, J.S. Buswell, S. Chiu.
- Jong S.C. et al., Medicinal and Therapeutic value of the Shiitake Mushroom. Adv. Appl. Microbiol. 1993; 39:153-84.
Beta-glucans differ in their solubilities depending on their size, functionality, and interaction with other molecules. In agreement with other organic chemists specializing in beta-glucan analysis, we have concluded that the currently employed methods are unreliable! Deciding to place a percentage on our labels gives us sufficient pause, as we know each methodology and each laboratory would yield a different result. There is no standard, accepted, validated methodology in the industry. This fact makes us reluctant to make any such claims on our product labels, and makes any purported beta glucan levels listed for any mushroom product dubious.
https://www.nammex.com/podcasts/
https://www.drkarafitzgerald.com/2019/01/31/medicinal-mushrooms-prescribing-what-works-jeff-chilton/?mc_cid=dc25a0fbeb&mc_eid=550cdb8753
pdf link Redefining Medicinal Mushrooms
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Does your mushroom product contain fillers like grain? Find out how to test. video
Many medicinal mushroom products are actually not made from mushrooms. What they are made from is the mushroom root system, mycelium, grown on grain and this grain cannot be separate from the mycelium so it ends up in the final product. This grain contributes a high amount of starch to the final product.
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