"Certain cells don't need insulin to bring in glucose and that is exercising muscles...so when your muscles are exercising - they can actually bring in glucose without insulin...in that exact moment it will lower blood sugar but actually it's the overall long-term effect that has the effect on pre-diabetes...type two is more of a metabolic issue... the cells become desensitized - visceral fat sends signals...certain chemicals that might make your body less sensitive to insulin... when you exercise a lot you start resetting your metabolism in a way...getting your body to utilize the macronutrients, glucose, fats, proteins, like it's supposed to...patients have gone into remission by exercising, losing visceral fat...changing the diet...all the blood markers improve..." Jonathan from the Institute of Human Anatomy
https://www.youtube.com/watch?v=_9ywulQF2Ho
Omega-3 goes UP for signaling in the brain... as the fatty acid to reduce the inflammation...
Amino acids go DOWN as you burn energy and more protein is needed to build muscle for repair as well as Saturated Fat goes down to burn energy and glycogen goes down as it is converted to glucose and the bad mitochondria damaged by reactive oxygen also goes down as it gets removed from the body....
Reactive Oxygen Species (ROS) are unstable molecules containing oxygen that readily react with other molecules, acting as crucial signaling agents in the body but also causing cellular damage (oxidative stress) if they build up, impacting processes like inflammation, aging, and cancer
Resistance training strengthens the muscles around the joint and actually makes inflammatory pain go away....sprinting versus jogging actually is more resistance training that is also aerobic - sprinting....
The pancreas increases insulin as you burn glucose from resistance training and this reactivates the insulation to fix insulin resistance. Burning fat from exercise and increased muscle mass improves insulin resistance...
if you insulin resistance the SAME molecule will go up in activation while if you are not insulin resistant the same molecule will go down in activation during the same exercise. So the insulin sensitive line and insulin resistance lines are completely inverted...meaning the same molecule goes UP if your sensitive and goes DOWN if your resistant...
you are what your body DOES with what you eat....
intense training forces blood through your microvascular system - for nitric oxide signaling increase....in the brain... and affects protein degradation...
If you have obesity and your fat calls are too big it sends mRNA code to the brain...causing leptin resistance in the brain, causing increased hunger and expending less energy....it's the FAT cells and obesity that are writing that mRNA CODE for leptin resistance instead of leptin sensitivity....ONCE you shrink the fat cells then you write the mRNA code of being less hungry and expending MORE energy relative to your body size....
insulin resistance people have lower glucose the next day if they do resistance training in the morning.... we KNOW you can improve your insulin resistance by building muscle...
Some get too much insulin but others doesn't get enough insulin
Glucose and fat are high in the blood stream...
Leptin resistance is different than insulin resistance but both are improved by the same methods....
one night of poor sleep increases ghrelin that makes a person hungry!!
carbs causes more insulin and more weight gain. Insulin is "converting excess energy into triglycerides (fat) in adipocytes (fat cells) and blocking fat breakdown (lipolysis)"...So a keto diet burns off more calories due to less insulin needed...
fat cells have an exaggerated tendency to store more fat based on leptin resistance and increased ghrelin... this is the "obesity phenotype" -
Fat tissue produces leptin... leptin tells you stop eating since you have enough fat...
Leptin resistance means the pathway no longer signals the leptin...
the Leptin receptor.. if you inhibit the inhibitor you promote the leptin signally....
A leptin pathway sensitizer ... when the fat cells expand - the leptin sensitivity is modified by the fat cell mRNA signals (sent to the brain in micro vesicles)
as body fat goes up then leptin goes up overall. Insulin stimulates leptin to double leptin secretion...
A cytokine is a hormone that regulates the immune system... TNFalpha works on fat cells as inflammation to stimulate the SAME fat cell to secrete MORE leptin...
Cholesterol is the foundation of all steroid hormones. For women cortisol and estrogen both stimulate leptin from fat cells...
Leptin activates the hypothalamus to create the feeling of fullness - satiety. Leptin then turns off the insulin... but if there is leptin resistance than insulin goes through the roof!!
so the insulin increase then increases the fat storage....
so if you control glucose by reducing carbs then insulin goes down....
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