Monday, May 27, 2024

Transgender Women being banned from Female track meet races: Oxytocin Neuro-receptors aka OXT

 "World Athletics Council, the governing body for international track and field, will bar transgender women athletes from elite competitions for women." and "National Association of Intercollegiate Athletics (NAIA) decided Monday that transgender women—or female gender–identifying individuals who were assigned male sex at birth—may not compete in its collegiate women’s sports going forward, CBS Sports reports." and "World Athletics Indoor Championships in Glasgow, Scotland, the governing body's President Sebastian Coe doubled down on the decision made by his Council, saying, without evidence, that had World Athletics not acted on the matter no woman would ever win another sporting event." 

 yeah it has to do with female mammals having twice as many oxytocin neuroreceptors that bond the babies to the females. Maybe we can get insurance to cover surgery to implant oxytocin neuroreceptors but I doubt it. 

see my post https://elixirfield.blogspot.com/2018/10/why-airport-trans-techno-feminist.html for more details on oxytocin neuroreceptors!  citing


"women had higher concentrations of OT in cerebral spinal fluid compared to men irrespective of health condition....suggesting that brain OT release may be higher in females,"

 "Male mice had fewer OT-immunoreactive fibers in the limbic system than females (Haussler et al., 1990). In particular, OT-immunostained neurons in the ventral ansa lenticularis, the perifornical region, and the lateral hypothalamus in male mice were almost absent (Haussler et al., 1990). OTR expression is modulated by sex hormones and shows obvious sex differences in brain regions across different species. Brain-region, species-specific, and sex-dependent expression of OTR is closely associated with some sex-dimorphic social behaviors (Dumais and Veenema, 2016)." Qiaoqiao Lu, Shaohua Hu,Chapter 5 - Sex differences of oxytocin and vasopressin in social behaviors, Editor(s): Dick F. Swaab, Felix Kreier, Paul J. Lucassen, Ahmad Salehi, Ruud M. Buijs, Handbook of Clinical Neurology, Elsevier, Volume 180, 2021, Pages 65-88,

https://www.sciencedirect.com/science/article/abs/pii/S0079612308004081 

 To further define the function of the oxytocin receptor (OXTR) in vivo, we generated mice deficient in the Oxtr gene (Oxtr−/−). Oxtr−/− mice had no obvious deficits in fertility or sexual behaviour, but displayed several aberrations in social behaviours, including male aggression, and mother–offspring interaction

 https://www.pnas.org/doi/abs/10.1073/pnas.0505312102

 These data suggest a developmental role for the OXT/OXTR system in shaping adult aggressive behavior. Our studies demonstrate that OXTR plays a critical role in regulating several aspects of social behavior and may have important implications for developmental psychiatric disorders characterized by deficits in social behavior.

https://www.sciencedirect.com/science/article/pii/S0002937817305653 

 We did not identify significant differences in the prevalence of oxytocin receptor variants between low-dose-requiring and high-dose-requiring women, but novel oxytocin receptor variants were enriched in the high-dose-requiring women. We also found 3 oxytocin receptor variants (2 novel, 1 known) that were predicted to damage oxytocin receptor function and would likely increase an individual’s risk for requiring a high oxytocin dose.

 Traditionally known for its role in milk let-down and uterine contraction during labor, OXT also has implications in physiological, and also behavioral, aspects of reproduction, such as sexual and maternal behaviors and pair bonding, but also anxiety, trust, sociability, food intake, or even drug abuse.

 However, in females, we found that genetic disruption of the Oxtr resulted in a greater consumption of alcohol both pre- and poststress compared to controls.

 

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