In this study, we identified differentially methylated CpG-sites in whole blood that are associated with self-reported tea consumption in women only, but not in men. Tea consumptions appear to be associated with DNA methylation in women. Women drink higher amounts of tea compared to men, which may increase the power to find associations in women. Results from previous studies have shown that tea consumption reduces estrogen levels by catechins and theaflavines that inhibit aromatase, an enzyme which catalyses the conversion of androgens to estrogens. This highlights a potential difference between the biological response to tea in men and women (30–32). We did not find an association between DNA-methylation and coffee, in either women or men.
https://academic.oup.com/hmg/article/26/16/3221/3848993
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