the release of atrial natriuretic peptide (ANP) into the circulation. Detailed analysis of the lesions showed that activation of oxytocin (OT)-ergic neurons is responsible for ANP release, and it has become clear that activation of neuronal circuitry elicits OT secretion into the circulation, activating atrial OT receptors and ANP release from the heart. Subsequently, we have uncovered the entire functional OT system in the rat and the human heart. An abundance of OT has been observed in the early development of the fetal heart, and the capacity of OT to generate cardiomyocytes (CMs) has been demonstrated in various types of stem cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982941/
The size of OTRs in rat heart appears to be identical to those in the uterus and other organs (24).
The highest OT concentration, as measured by radioimmunoassay, was found in the right atrium and was comparable with OT content in the hypothalamus (25); the lowest levels in the heart were found in the ventricles. Amplified fragments of OT genes from the rat heart were identical in size to those in the uterus.
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