Wednesday, August 26, 2026

the diagnosis of ‘cannabis psychosis': self-medicated Cannabis use causes paranoid "schizoid" traits especially in males

 Schizophrenia Bulletin vol. 41 no. 2 pp. 391–399, 2015
doi:10.1093/schbul/sbu098
Advance Access publication July 16, 2014© The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/),
which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
How Cannabis Causes Paranoia: Using the Intravenous Administration of
∆9-Tetrahydrocannabinol (THC) to Identify Key Cognitive Mechanisms
Leading to Paranoia

Cannabis paranoid Schizoid 

 Conclusions Initiating cannabis use for self-medication
is associated with higher average THC consumption, and
increased anxiety, depression and paranoia.

 In four cross-sectional studies from the general population, the odds of displaying paranoid symptoms in cannabinoid users was higher than in non-users (OR: 1.75, 95 % CI, 1.43–2.07, PPI: 99 %), with effects increasing with the percentage of males in the sample. The pooled effect was not significant in studies recruiting patients with psychiatric disorders. Results of three prospective studies also suggest that cannabis is associated with the subsequent onset of paranoid symptoms. 

 https://www.sciencedirect.com/science/article/pii/S0149763425002702

 the diagnosis of ‘cannabis psychosis' as a distinct clinical entity.

https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/abs/psychiatric-symptoms-in-cannabis-users/CFC8BA3F34C6A972118607202046CB3F 

 https://www.sciencedirect.com/science/article/abs/pii/S0091305796004261

Towards a Cannabinoid Hypothesis of Schizophrenia: Cognitive Impairments Due to Dysregulation of the Endogenous Cannabinoid System

  significant causal associations between CUD and an increased risk of emotionally unstable PD (EUPD; ORIVW = 1.228, 95% CI 1.069–1.411), overall PD (ORIVW = 1.186, 95% CI 1.065–1.321), and schizoid PD (SPD; ORIVW = 1.644, 95% CI 1.131–2.39

https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1411587/full 

https://scholarworks.wmich.edu/cgi/viewcontent.cgi?article=4755&context=honors_theses 

 https://scholarsrepository.llu.edu/cgi/viewcontent.cgi?article=3614&context=etd

 

 

 

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