the researchers for the first time reveal that CA1 and CA2 respectively encode the locations and individuals linked with a threatening experience. The results show that, beyond simply recognizing individuals, CA2 helps record more complex aspects of social memory: in this case, whether another individual is safe or risky. The scientists published their findings October 15 in the journal Nature Neuroscience.
"It's vital to all species that live in social communities, including mice and humans, to have social memories that can help one avoid future experiences with others that might prove harmful while keeping ourselves open to individuals who may be beneficial," said Pegah Kassraian, PhD, a postdoctoral research fellow in the Siegelbaum lab and lead author of the new study.
https://zuckermaninstitute.columbia.edu/fearful-memories-others-seen-mouse-brain
Silencing dCA2 during encoding or recall trials disrupted social fear discrimination memory...When they silenced CA2, the mice remembered where they were shocked, but became indiscriminately afraid of both strangers they met.
https://www.nature.com/articles/s41593-024-01771-8
CA2 helps mice remember whether past encounters with others were threatening or safe. The results also are consistent with prior research detailing how CA1 is home to place cells, which encode locations.
When the scientists silenced CA1, the mice could no longer remember where they were zapped, but they could still remember which stranger was associated with the threat.
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