Subjects who had used the mouthwash longer (>35 years) also had an increased risk of upper airway cancer (OR: 1.15; 95%CI = 1.01 - 1.30), as well as those using it more than once per day (OR: 1.31; 95%CI = 1.09 - 1.58).
As in the previous two studies, Guha N. et al. (31) confirmed the positive relationship between mouthwash use and cancer (oral, pharynx or larynx cancer).....
In this study, a significant increase of acetaldehyde concentration in saliva was observed in the three samples of mouthwash with ethanol at 30 seconds, 2 and 5 minutes, with a subsequent decrease. The maximum peak was between 30 seconds and 2 minutes. On the other hand, Gandini et al. (5) did not find differences in oral or pharyngeal cancer according to mouthwash use (OR: 1.13; 95%CI = 0.95 - 1.35). No differences were found between mouthwash use and non-use in terms of risk for oral cancer (RR: 0.99, 95%CI = 0.75 - 1.31, I2 = 19%, P-χ2 = 0.30).
The relative risk summary estimates for 1-3 times a day of mouthwash showed a dose dependent trend but with no statistically significant increased risk for oral cancer, compared to no exposure: 1.19 (95%CI = 0.95 – 1.5), 1.42 (95%CI = 0.91 – 2.24) and 1.7 (95%CI = 0.86 – 3.35), respectively, with I2 = 76% and Chy-square p<0.001....
The acetaldehyde levels in saliva were significantly higher in subjects who occasionally washed their teeth (c1) and in subjects with 1-2 washes/day (c2) than in subjects with ≥3 daily washes (c3) (Kruskal-Wallis: 13.19, p<0.01),
https://pmc.ncbi.nlm.nih.gov/articles/PMC6982979/
So make sure to wash out the mouth and brush the teeth after alcohol-based mouthwash is used!
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