Saturday, February 7, 2026

Why Rosemary Oil makes me "drunk" as GABA agonist: Eucalyptol

 Rosemary oil is at least 35% 1,8 cineole (eucalyptol) that is a GABA agonist. More than any other essential oil I've taken, Rosemary Oil gets me feeling seriously drunk....

 The eucalyptol terpene known for its antiseptic, anti-inflammatory, and antioxidant properties.

The concentration of
1,8-cineole (also known as eucalyptol) in rosemary oil typically ranges between 38% and 55%

so I have to be careful. AI says:

The main active terpenes in rosemary oil (often comprising over 30 individual components) are
1,8-cineole (eucalyptol),
αalpha
-pinene
, and camphor
.

1,8-Cineole (eucalyptol) is a natural monoterpene that
acts as a positive modulator of the GABAergic system, contributing to anti-anxiety, antidepressant, and anti-seizure effects. It often acts on
GABAAcap G cap A cap B cap A sub cap A
receptors to reduce neuronal excitability, but its role in seizures can be complex. It also exhibits anti-inflammatory and TRPM8 agonist properties.
Key Aspects of 1,8-Cineole and GABA/Neurological Function:
  • GABAergic Modulation: 1,8-cineole can modulate the GABAergic system, which is crucial for reducing anxiety and managing epilepsy.
  • Anxiolytic/Antidepressant: Studies indicate that 1,8-cineole has anxiolytic (anti-anxiety) and antidepressant-like effects, partly mediated by the
    GABAAcap G cap A cap B cap A sub cap A
    receptor.

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