Studies have shown that extracts from Taraxacum officinale have anti-tumor properties and can inhibit the growth of cancer cells in various types of cancers such as breast, prostate, colon, and liver cancer [1].https://foodchemistryjournal.com/jfcn/articles/v9s1/jfcn-s1-sham-su-zuha.pdf
Dandelion contains a variety of phytochemicals, including flavonoids, phenolic acids, ses-
quiterpene lactones, polysaccharides, triterpenoids, and other compounds (Figure 1)
Dandelion contains several flavonoids, including luteolin, apigenin,
chrysoeriol, and quercetin. Luteolin is a flavone that has been shown to have antioxidant, anti-inflammatory, and anti-cancer properties. Studies have shown that luteolin can reduce
inflammation by inhibiting the production of inflammatory cytokines and enzymes.
The results showed that this extract selectively induced
programmed cell death in more than 95% of colon cancer cells
within 48 hours of treatment, regardless of their p53 status.
In addition, in-vivo studies confirmed the anti-cancer effica-
cy of this extract as oral administration significantly inhibited
the growth of human colon xenograft models by more than
90%. The study also revealed the activation of multiple death
pathways in cancer cells by dandelion root extract treatment,
as indicated by the expression of genes related to programmed
cell death seen in gene expression analyses. Overall, these
findings suggest that the dandelion root extract has promising
potential as an effective treatment for colon cancer, although
further research is needed to confirm its safety and efficacy in
humans [32].These findings demonstrate that DRE preferentially kills malignant cells while being harmless to healthy cells.
It is commonly recognized that many chemotherapies have
very serious side effects, mostly because these medications do
not target solely cancer cells and occasionally only work at
extremely large doses.dandelion root extract (DRE)
https://www.mdpi.com/2072-6643/15/1/80
https://www.sciencedirect.com/science/article/abs/pii/S0378874125000911
Dandelion contains different sesquiterpenoid and phenolic compounds. The bitter taste of dandelion is mainly imparted by sesquiterpenoids (Figure 2).
https://www.nature.com/articles/s41598-023-42177-z
Combined dandelion extract and all-trans retinoic acid induces cytotoxicity in human breast cancer cells
https://www.wcrj.net/wp-content/uploads/sites/5/2022/07/e2361.pdf
Dandelion root extract's (DRE) antioxidant, antimicrobial, and cytotoxic effects. The Gas Chromatography-Mass Spectrometry (GC–MS) result revealed the presence of bioactive compounds such as P-hydroxybenzoic, chlorogenic acid, vanillic acid, caffeic acid, lupeol, leutolin, apigenin, coumestrol and much more that are present in the DRE extract.
https://www.sciencedirect.com/science/article/abs/pii/S0944711322000642
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