Thursday, April 3, 2025

Intermittent Fasting and ginger (especially shogaol from heating ginger) prevents cancer

 Switching to burning fats instead of sugars...

at least we have ketosis fasting or eating a fat diet if we need too maybe? Cancer cells "can not burn fatty acids or ketones" - very fascinating!! https://www.youtube.com/watch?v=KjdAtauO2cA - I figure intermittent fasting should be good enough. (see study below) So fasting every day should clean out the body of bad cells.  yeah looks like Intermittent Fasting is definitely the best preventative to "clear out" any cancer cells... not just glucose (this article doesn't acknowledge the glutamine key)... He also says "acidifying the microenvironment" - that's precisely what qigong master Chunyi Lin says - that cancer feeds off glucose and acidity! Fascinating.
Intermittent fasting induces a state of ketosis, where the body shifts from glucose to ketone bodies as a primary energy source [4]–[6]. This metabolic switch can be detrimental to cancer cells, which rely heavily on glucose for rapid proliferation. Intermittent fasting also impacts the immune system, enhancing its ability to target and destroy cancer cells. Studies have demonstrated that fasting can increase the activity of natural killer (NK) cells and cytotoxic T lymphocytes, which play crucial roles in the immune response against tumors [7], [8]. Moreover, fasting has been observed to decrease the levels of proinflammatory cytokines and increase anti-inflammatory markers, creating a less favorable environment for cancer progression [9], [10].
https://ej-clinicmed.org/index.php/clinicmed/article/view/345
 
 https://pubmed.ncbi.nlm.nih.gov/30327499/

Fasting and cancer: molecular mechanisms and clinical application 

 https://pubmed.ncbi.nlm.nih.gov/36646607/

 https://www.youtube.com/watch?v=ERoP6pE7CCk

 https://www.youtube.com/watch?v=96hu4p98T20

 https://www.youtube.com/watch?v=TAavt5ghaHs

 It has been confirmed by numerous experimental studies that 6-shogaol exhibits strong anti-proliferative activity against various types of tumors, including breast, liver, cervical, oral, colon, and renal cancers

https://onlinelibrary.wiley.com/doi/abs/10.1002/masy.202200108 

  A molecular docking study shows that shogoal, demethoxycurcumin, capsaicin, ellagic acid, 6-paradol, 6-gingerol, carnosic acid, and curcumin bind strongly with the cancer target: human DNA topoisomerase-III alpha. In silico absorption, a study reveals that only cinnamic acid, allicin, alpha turmerone, cinnamyl acetate, and carnosic acid have more than 96% human intestinal absorption, but only alpha turmerone can cross both the blood–brain barrier and central nervous system. In silico phase-I, the metabolism study shows 6-paradol and carnosic acid as substrates for cytochrome 450 enzyme (CYP450 3A4) and curcumin and dillapiol as inhibitors for CYP 450 2D6. Overall the study concludes that small phytochemicals present in different spices have the potential to be proposed as oral anti-cancer drugs against cancer targets DNA topoisomerase III alpha.

 Cited Resources • Chueahongthong F, Tima S, Chiampanichayakul S, et al. Co-Treatments of Edible Curcumin from Turmeric Rhizomes and Chemotherapeutic Drugs on Cytotoxicity and FLT3 Protein Expression in Leukemic Stem Cells. Molecules. 2021 Sep 24;26(19):5785. doi: 10.3390/molecules26195785. PMID: 34641328; PMCID: PMC8510311. https://pubmed.ncbi.nlm.nih.gov/34641328 • Crichton M, Marshall S, Isenring E, et al. Effect of a Standardized Ginger Root Powder Regimen on Chemotherapy-Induced Nausea and Vomiting: A Multicenter, Double-Blind, Placebo-Controlled Randomized Trial. J Acad Nutr Diet. 2024 Mar;124(3):313-330.e6. doi: 10.1016/j.jand.2023.09.003. Epub 2023 Sep 10. PMID: 37699474. https://pubmed.ncbi.nlm.nih.gov/37699474 • Lapidot T, Sirard C, Vormoor J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994 Feb 17;367(6464):645-8. doi: 10.1038/367645a0. PMID: 7509044. https://pubmed.ncbi.nlm.nih.gov/7509044 • Panyajai P, Viriyaadhammaa N, Chiampanichayakul S, et al. Anticancer and cancer preventive activities of shogaol and curcumin from Zingiberaceae family plants in KG-1a leukemic stem cells. BMC Complement Med Ther. 2025 Feb 28;25(1):87. doi: 10.1186/s12906-025-04829-7. PMID: 40022126; PMCID: PMC11869560. https://pubmed.ncbi.nlm.nih.gov/40022126 • Shidfar F, Rajab A, Rahideh T, et al. The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes. J Complement Integr Med. 2015 Jun;12(2):165-70. doi: 10.1515/jcim-2014-0021. PMID: 25719344. https://pubmed.ncbi.nlm.nih.gov/25719344

 

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