Sunday, December 15, 2024

Serotonin neurotransmitter 5-HT2A agonists (Tobias Buchborn) induces hyperthermia - increased body heat (Wim Hof tummo effect via vagus nerve)

 “hyperthermia in neuroleptic malignant syndrome is due to the dominant effect of serotonin in the thermoregulatory center either by blocking the dopamine receptor or by enhancing the serotonin secretion.” []. It is accepted that increasing serotonin neurotransmitter concentration in the brain favors the development of hyperthermia (Serotonin Syndrome; SS) 

https://pmc.ncbi.nlm.nih.gov/articles/PMC8952796/ 

  In conclusion, stimulation of 5-HT1A receptors causes central sympatho-inhibition and an increase in cardiac vagal drive [].

 Activation of 5-HT2A and 5-HT2B receptors has predominantly excitatory effects. Some authors understand SS as a consequence of excessive activation of 5-HT2A receptors []. The available evidence supports the view that activation of these receptors is associated with hyperthermia,

 Why DMT works all the time and LSD won't - Tobias Buchborn 

 Based on the theoretical model presented the “ideal” antidote against serotonin syndrome hyperthermia appears to be an antagonist at the 5-HT receptor subtypes 2, 4 and 6 and an agonist at the receptor subtypes 1, 3 and 7. Very broadly speaking, such a profile translates in a sympatholytic effect.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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