We found strong support for a single extended period of Neanderthal gene flow into the common ancestors of all non-Africans that occurred between 50,500 and 43,500 years ago. These dates provide a lower bound for the timing of the out-of-Africa migration and settlement of regions outside Africa. The majority of natural selection—positive and negative—on Neanderthal ancestry happened very quickly after the gene flow and left clear signals in the genetic diversity of the earliest modern humans outside Africa.
https://www.youtube.com/watch?v=lRXZjv7iM5k
From Neanderthals to Plants to Pathogens: Human Co-evolution With Other Organisms
East Asians have about 2% Neanderthal ancestry - the highest amount of any non-Africans.
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