Sunday, May 8, 2022

Tea Tree Oil as Gut protection? terpinen-4-ol and China

 https://www.frontiersin.org/articles/10.3389/fnut.2021.805612/full

 Tea tree oil (TTO) is extracted from Melaleuca alternifolia. Because of its broad-spectrum antimicrobial (bacteria, fungi, and viruses), anti-cancer, anti-tussive, and antioxidant properties (12). TTO is widely used to treat acne, athlete's foot, and contact dermatitis. TTO contains over 100 components, including terpineol, zinc, and diheptoxy-sulfanylidene-sulfido-λ 5–phosphane (13), the most crucial being terpinen-4-ol (TER), which accounts for >30% of all TTO components.

I've arguably digested more Tea Tree Oil than any human on the planet! So this study is good news for me. haha.

 It has also been used as a spice to reduce breast cancer incidence (16). Mechanistically, TER can downregulate the secretion of the inflammatory signaling molecule, NO, which is induced by lipopolysaccharide (LPS) and dioctyl sodium sulfosuccinate (DSS) (17, 18). In addition, TER plays a role in regulating the mitogen-activated protein kinase (MAPK)-signaling pathway (19), which is intimately involved in the expression of TJ proteins (20). Hence, we hypothesized that TER would be a promising candidate for IBD therapy.

 TER has attracted considerable interest as a bactericidal product in potential applications due to its unique biological activity, including antibacterial and antioxidant activities. Our study showed that TER protected IPEC-J2 cells against LPS-induced inflammation and DSS-induced colitis. Furthermore, we also showed the role of TJ proteins in LPS-or DSS-induced gut barrier damage via the ERK1/2-signaling pathway (Figure 10).

hmm - I wonder who funded the study?

 https://www.frontiersin.org/files/Articles/805612/fnut-08-805612-HTML-r1/image_m/fnut-08-805612-g010.jpg

 This study was supported by National Natural Science Foundation of China (Nos. 31472243 and 31902314), Natural Science Foundation of Guangdong Province, China (No. 019A1515011142), and Project of Enhancing School with Innovation of Guangdong Ocean University (No. GDOU230419057).

 Wow - Guangdong, that's where Chunyi Lin is from....

 

 

 

 

 


 

 

 

 

 

 

 

 

 

 

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