Friday, February 5, 2021

Noncommutative anharmonic oscillations as Isentropic drive of cellular life? updates on the Heimburg, Jackson, et. al. Sound-Neuron model of reality

 Thanks for a regular reader who discovered my research 12 years ago - and sent me this update. 

 This formalism, valid close to equilibrium, is generally applied to describe irreversible processes (e.g., diffusion and heat dissipation); far-from-equilibrium systems still display a coupling between fluxes and forces, however the coupling is no longer linear because the entropy constitutes a non-harmonic potential.

In a recent paper [], Onsager’s theory was revised in depth, and a new formalism proposed that also considers the antisymmetric part of the phenomenological matrix, which relates to isentropic processes.

So Western science thinks of "harmonic" as symmetric math but we know from Alain Connes (and my own personal music insights) that real harmony is asymmetric or noncommutative phase logic!

And so this was picked up by the Hameroff-Penrose research group, and corroborated in my own correspondence with them - in other words the original of formless awareness is from noncommutative phase that in science is called Anharmonicity.

In classical mechanics, anharmonicity is the deviation of a system from being a harmonic oscillator.

 Anharmonic oscillation is described as the restoring force is no longer proportional to the displacement.

So biologist Professor Brian Goodwin in his chaotic biology research emphasized that there is a "significant amplification" of energy due to the "subharmonic of frequency."

I recently noticed someone responding to one of my 2006 articles - or was it earlier - on Gurdjieff - stating that this claim was impossible since a change in "phase" in no way could change the "amplitude" or "frequency", etc.

Anyway obviously I'm not a scientist but it appears that more scientists are picking up on this noncommutative phase logic. This research is from the "neurons as powered by sound or phonon acoustic vibrations" - claim - as was pointed out to me - research I had cited some 12 years ago!

 As a consequence, we propose an alternative framework of interpretation for the emergence of oscillating processes in biological systems, namely, that oscillations arise as a consequence of a nearly isentropic state of non-dividing S. cerevisiae cells using fermentation as the sole source of energy. Based on previous results from our laboratory [, ], it seems entirely plausible that the coupling principles that link chemical transformations with the thermodynamics of the system may be fruitfully approached as a natural consequence of the highly structured nature of cytoplasm, conceptualized in terms of the association-induction hypothesis (AIH) proposed by G.N. Ling [] (recently discussed in []), where ATP production and the dynamics of intracellular water are mechanistically linked (see Discussion section).

 right - the email I got explained this aspect of incorporating the 4th state of water - the negentropic macroquantum coherent phase of water. Also the cellular model of Ling - I had forgotten about this. I think Mae-Wan Ho relied on Ling's cellular model - it seems that maybe most quantum biologists rely on Ling's cellular model.

So if I remember correctly - this means the potassium has a higher potential energy that stores up the energy - and that fits precisely with the Yang Qi model I had claimed. I have to review my own "training manual" - someone PM'd me for a link to it - this AM. I think I cite Ling's cell model in that training manual.

The adiabatic nature of the nerve pulse combined with the mechanical changes and the physical size of the pulse, indicates that the nerves pulses could be a type of sound wave. This deduction lead to the proposal of the Soliton model by Heimburg and Jackson in 2005 [26]. 2014 Soliton Sound nerves Ph.D. thesis pdf …. The soliton is locally pushing the lipid membrane into its lipid melting transition as it propagates….The propagation of the soliton will result in changes in thickness of the membrane and also have an electrical component, both observed during the propagation of nerve signals….Interestingly the inverse piezoelectrical e ffect means that an electrical change has a mechanical response,allowing for a coupling between electrical stimulation and the excitation of a soliton….This means that the dispersion and non-linearity of the speed of sound are tightly coupled through their dependency on the state of the lipid membrane….Timescales found for the dynamics of pores in lipid membranes are rather on the millisecond regime which predict solitons with a width of z [approx.]10 cm for L = 1:39 1012J K=(s mol). Nerve pulses in myelinated axons have a width of the order of z [approx.] 10 cm which seems within the predicted range….The Soliton model, unlike the Hodgkin and Huxley model, predicts that nerve
signal propagating down the same axon can pass through one another without annihilation [42, 110]….We demonstrated that nerve pulses can penetrate each other in both myelinated
preparations (earthworms) and in non-myelinated preparations (lobster). Penetration is predicted by the Soliton model, whereas it seems contradictory with respect to the prediction of the Hodgkin and Huxley model….The typical timescale of a nerve pulse is 1 ms, corresponding to a characteristic frequency in the range up to 1 kHz….All previous attempts to explore sound propagation in lipid membranes have focused on the ultrasonic regime [9,14–16], and it has clearly been demonstrated that dispersion exists in this frequency regime….nerve fibers swell during the nerve pulse [37{39, 114, 115]….the Soliton model the mechanical changes are the one that cause the electrical signal and they represent two aspects of the same pulse….other membrane adhesive molecules with large dipoles can be used to create an asymmetric membrane, e.g., soluble proteins or lipid-associated molecules such
as long-chain sugars. Depending on the nature of the asymmetry, the system can display piezoelectric properties.

 OK so I cite their research - but I guess not Ling.

I guess I didn't realize that the corroboration of the Hameroff Penrose model ALSO corroborates THIS model as it relies on ultrasound.

OK back to the research paper.

Recently, one of us has proposed that the coupling matrix L__ does not have to be symmetric []. Any matrix can unambiguously be written as the sum of a symmetric and an antisymmetric matrix

Excellent - just as I uploaded on youtube about negentropy - the noncommutative phase logic is starting to be embraced.

  It follows that the antisymmetric part describes entropy-conserving phenomena such as oscillations of a spring or an electrical LC circuit, and also chemical oscillations.

 If the hypothesis being examined [] is even partly valid for our system, the antisymmetric phenomenological matrix does not contribute to dissipation and oscillations in temperature should involve cyclic release and absorption of heat.

 That certainly jives with the meditation practice! You store up a great amount of heat and then can release it as healing energy!

In recent studies, we established that glycolytic oscillations are tightly coupled with the global state of intracellular water and that this phenomenon is scale-independent (i.e., it is observed for cellular sub-volumes, whole cells and cell populations) [, , ].

 very fascinating indeed. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701229/ 

We established that water dipolar relaxation - a measure of the freedom of water dipoles to reorient in response to changes in dipole moments - oscillates with glycolysis and is in phase with intracellular ATP levels. Furthermore, this phenomenon was shown to be scale-invariant from the subcellular level to ensembles of synchronized cells. So far, none of the existing models of glycolytic oscillations can account for this coupling between the physical state of water and a metabolic process.

 cool research.

suggest that most intracellular water is in a gel-like or polarized state, while other reports indicate that intracellular water is essentially like bulk water.Although the idea has not yet been thoroughly explored in biological contexts, it is not unusual for non-biological oscillating chemical reactions to respond to macromolecular crowding. For example, it is well known that the Belousov-Zhabotinskii (BZ) reaction, when carried out in viscous aqueous solutions containing various polymers, may show oscillations in solution viscosity and volume that are synchronized with oscillations in redox potential.

 So this is quantum chaos biology! wild.

oscillating glycolysis are linked mechanistically can be provided by the Association-Induction hypothesis (A-I hypothesis) developed by G. Ling. Briefly, this hypothesis proposes that the association of some central metabolites (e.g., ATP) with fibrillar proteins (i.e., those forming the cytoskeleton) causes conformational changes. In turn, these modulate the binding affinity of particular ions for proteins and the patterns of hydrogen bonding to water (as described by the polarized-oriented multilayer theory of cellular water,) and, hence, the partition coefficients of numerous molecular actors. We believe that the A-I hypothesis is relevant in light of the observed relationship between ATP and the oscillations of intracellular water dynamics. First, we found in a previous study, and confirmed here (see Fig. S3), that during oscillatory glycolysis, oscillations of the DAN probes are strictly in phase with the ATP oscillations,. Second, as reported in this paper, the experiments with iodoacetate and 2-deoxyglucose, which alter the normal production of ATP in the cell, inhibit the oscillations measured in NADH and ACDAN GP and push the ACDAN GP out of the oscillatory GP region.

OK so it's nice to see their biology model has really expanded...

Interestingly, this model may provide an explanation for why oscillations appear cell-wide and most cellular regions seem to oscillate in phase. Given restrictions on diffusion in crowded environments, a mechano-chemical coupling via structured or polarized water, which is controlled by adsorption of ATP to proteins and other intracellular surfaces, can account for an almost instantaneous spatiotemporal coupling of the oscillations. Conversely, cellular regions where glycolytic oscillations are absent may show oscillations in the polarization of water coupled to the polarization of water in the regions exhibiting glycolytic oscillations, but with a slight phase shift (Figure S18).

So this is precisely what to look for - phase shifts that enable synchronization over different spacetime scales. 

OK so that was the previous water focused study they cited. So now back to the asymmetric low entropy study that emphasizes not only a change in frequency and phase but ALSO a change in amplitude and entropy!!

This is strong evidence that chemical oscillations contain reversible adiabatic contributions. Reversible temperature changes have also been found in nerve pulses, which indicates that adiabatic processes are also possible in biology (for a review see []).

Taken together, our results on the oscillatory coupling between cellular volume, heat, metabolites (NADH in this case), and temperature support the idea that an isentropic state is maintained during glycolytic oscillations. This is rarely considered in biological systems, in which dissipative processes are assumed to dominate all functional aspects of cellular phenomena.

is·en·trop·ic
/ˌīsənˈträpik,ˌīzənˈträpik,ˌīsənˈtōrpik/
adjective
Physics
having equal entropy.

https://sci-hub.se/10.1039/c7cp02189e

 In this paper we
focus on the antisymmetric contributions which describe isentropic oscillations with well-defined equations
of motion. The formalism contains variables that are equivalent to momenta and coefficients that are
analogous to inertial mass.

and so:

Right so basically through meditation you can "exorcism" or reverse the entropy created during the day. I compare it to developing a photograph - you need a dark room to do it properly but it's a conscious process (not sleeping). So if you just keep the lights on - then the film gets overexposed or whatever.

So Ramana Maharshi uses the metaphor of a movie film such that the empty Screen behind the film is the truth of reality - and only by turning the light around of the film projector do we then realize that we can not even see the film because the screen now is flooded with light.

So spacetime is the film going through the projector but the "screen" remains hidden from view since it just gets flooded with light.

So we can listen to the source of the energy but we can't see it. Yet the light itself is what provides the means to observe the movement of spacetime itself.

This does not mean that spacetime is NOT moving if we can not perceive it moving.






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