Tuesday, May 19, 2020

Ginger is the best natural treatment for Covid-19? theaflavin 3,3'-digallate

It is also interesting that theaflavin 3,3'-digallate, a
phenolic compound present in ginger, was found to interact both with ACE2 receptor...with considerable biding affinities. Our present
finding of theaflavin 3,3'-digallate and previous results regarding to phenolics as hits
(8) prompted us to consider their effects against SARS-CoV-2 might be also
associated with their antioxidant potency. With this rationale, we tentatively suggest
that marketed antioxidants such as edaravone and intake of ginger with high content
of phenolics might be beneficial for SARS-CoV-2 patients. Unfortunately, this
hypothesis and therapeutic approach has been largely ignored during SARS-CoV-2
outbreak.

Discovery of anti-SARS-CoV-2 agents from commercially available
flavor via docking screening

Jiao-Jiao Zhang1,†, Xin Shen2,†, Yong-Ming Yan1, Yan Wang2,*, Yong-Xian Cheng1,*
1 School of Pharmaceutical Sciences, Shenzhen University Health Science Center,
Shenzhen 518060, P.R. China
2 Center for Translation Medicine Research and Development, Shenzhen Institute of
Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P.R. China

pdf link

ginger inhibits ACE

 Given that the druggable antiviral target ACE2
receptor and viral main protease were reported, 169 compounds were screened against
these two targets by using autodock vina. According to our docking screening, 10
antiviral components, including glycyrrhizic acid, theaflavin 3,3'-digallate, agnuside,
fenflumizole, angelicide, sageone, oleanic acid, benzyl (3-fluoro-4-morpholine-4-yl
phenyl) carbamate, glycerol ester of rosin, and endere S can directly bind to both host
cell target ACE2 receptor and viral target main protease, indicating their potential for
SARS-CoV-2 treatment.

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