Wednesday, February 12, 2020

2.5 times MORE Lentinan in log grown forest shiitake or 香菇 mushrooms - for anti-viral medicine food as Lentiavidins










https://www.mushroomcompany.com/resources/shiitake/ala-logs.pdf

https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.lb391

Lentinen - Anti-tumor

  • Analyses for total starch and glycogen, to a lesser extent, indicate these polysaccharides are less than 10% of the total carbohydrates in HMWP. These results suggest that the HMWP fraction had a high level of lentinan.
I did a blog post on this last year.

https://elixirfield.blogspot.com/2019/02/chinese-black-mushroom-is-shiitake-to.html

  So we are excited to see new studies about proteins in shiitake mushrooms called lentiavidins. You might recognize the "avidins" part of this name from research on egg whites. Avidins are egg-white proteins that can bind together with biotin. In the case of shiitake, researchers have added the designation "lenti"—from the shiitake genus Lentinula—to come up with the new protein name, "lentiavidins."
Lentinan, an immunostimulant derived from shiitakes, has been used to treat cancer, AIDS, diabetes, chronic fatigue syndrome, fibrocystic breast disease, and other conditions with impressive results.

香菇
 

 http://www.goba.eu/wp-content/uploads/2015/06/Mushroom_Growers_Handbook_2_-_Shiitake_Cultivation.pdf







Shiitake has interested researchers due to its medicinal properties, and several biologically active compounds have been isolated and purified from the mushrooms, mycelia and aqueous extract (Chang, 1999; Ishikawa et al., 2001; Hassegawa et al., 2005). These compounds exhibit antitumoral, antifungal, antibacterial, hypoglycemic and antioxidant properties (Maeda et al., 1998; Ngai and Ng, 2003; Ishikawa et al., 2001; Yang et al., 2002; Kitzberger et al., 2007) that can have one or more therapeutic effects and can act synergistically (Pascholati et al., 1998; Wasser and Weis, 1999). Among these compounds, some of the best characterized are lentinan (Chihara et al., 1969; Minato et al., 1999), KS-2, (Fujii et al., 1978), lentinacin (2(R), 3(R)-dihidrixi-4-(9 adenil)- butyric acid), known as eritadenine (Shimada et al., 2003a; Shimada et al., 2003b, Enman et al., 2008), and fruit body protein -(FBP), which inhibits the tobacco mosaic virus (Kobayashi et al., 1987. Lentinamycin (octa-2, 3-diene-5, 7-diyne-1-ol) was isolated and purified from a liquid culture of L. edodes (Bew et al., 1966). This compound inhibits the growth of Trichoderma sp (Tokimoto et al., 1987) and Gram-positive bacteria (Komemushi et al., 1996). T
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500017

Wow - so as my shiitake log mycelium fight off the Trichoderma invasion - they are increasing their lentinamycin levels and therefore also their Lentinan levels! This is why Lentinan is higher in log grown mushrooms.... in the forest, grown in the wild.

possible mechanisms of lentinan


variation of bioactive lentinan-containing preparations in ... PDF by MMM TOMASSEN - ‎Cited by 7 - ‎Related articles The immunomodulatory activities of ß-glucans depends on their degree of ... Lentinula pdf


Edible and medicinal mushroom Lentinus edodes (Shiitake) contains an antitumor polysaccharide, lentinan. In a previous report, we ascertained that low-temperature storage was fairly effective for maintaining the contents of lentinan, and the degradation of lentinan during storage at 20 °C was caused by the increase of glucanase activity.
Changes of Lentinan Contents and Glucanase Activity in Lentinus edodes (Berk.) Singer (Agaricomycetideae) Stored Under Controlled Atmosphere

https://www.researchgate.net/scientific-contributions/76228908_Keisuke_Tokimoto

finding that a 5 h forcing treatment resulted in the greatest yield. ...
Five hour Log "forcing" resulted in greatest yield! Awesome news.

Effects of Management on the Yield and High-Molecular-Weight Polysaccharide Content of Shiitake (Lentinulaedodes) Mushrooms

High-molecular-weight polysaccharides (HMWP) including lentinan in shiitake may promote human health. This study was conducted to determine if management protocols influence the HMWP of shiitake mushrooms. Results indicate that measuring the total carbohydrate content of water-extractable, ethanol-insoluble polysaccharides was a simple way to estimate HMWP. Results also indicate that log-grown shiitake contained more HMWP than did substrate-grown shiitake.



So lowers cholesterol...





There it is!! Finally. The source of the 2.6 times more lentinan claim!























and strain?







So Westwind is by far the preferred strain for Lentinan production! amazing info.



https://journals.ashs.org/hortsci/view/journals/hortsci/41/3/article-p514A.xml
Shiitake mushrooms contain lentinan, a polysaccharide that has numerous medicinal benefits. The objective of this research was to determine the impact of various rates of chipped and sawmill bark added to the substrate on lentinan found in shiitake mushrooms. Crude polysaccharide extract (CPE) and lentinan (LTN) content was significantly different among shiitake mushrooms grown on various artificial substrates containing different percentages of sawdust and chipped bark. The addition of chipped bark content from 0% to 50% increased the CPE content, but an increase in chipped bark content from 50% to 100% decreased the CPE and LTN content. CPE content in mushrooms was greater when equal proportions of sawdust and bark were used. A 100% heartwood treatment had the least CPE content.

and so Shiitake is now used to inhibit growth of wheat leaf blight disease ! And Shiitake is used to replace antibiotics for pigs

Only the diet containing 5% of dried L. edodes consistently resulted in lower viable counts (ca. 1 – 2 log10 CFU) of total bacteria, E. coli, streptococci and lactic acid bacteria, and luminal and mucosal effects agreed very well. With this diet, acetate and butyrate concentrations in the distal jejunum were doubled, which is favourable in view of the trophic effect on enterocytes and colonocytes.
It should be taken into account that the influence of L. edodes mycelium powder was more likely due to the presence of antibacterial compounds (eg. lenthionine, lentinamycin, terpenoids, polyphenols), rather than to an immunostimulating action of β-glucans with increased release of IgA onto the mucosa surface.
Fresh and refrigerated - maintain best Lentinan levels at 40 F.
The lentinan contents in the Lentinus edodes fruit body during storage were examined by ELISA method using anti-lentinan antibodies. The lentinan content (12.8 mg.g(-)(1) dw) before storage decreased to 3.7 mg.g(-)(1) dw over 7 days at 20 degrees C. However, it only slightly decreased at 1 degrees C and only decreased to 9.3 mg. g(-)(1) dw at 5 degrees C. Glucanase activity, which seems to be associated with lentinan degradation, increased more during storage of L. edodes at 20 degrees C than it did at lower temperatures. In addition, only glucose was detected as a degraded product from lentinan by the glucanase. This suggested that this enzyme would fit the profile of an exo-type glucanase. Also, polyphenol oxidase activity, known as an index of freshness reduction in the mushroom, increased approximately 2.7-fold (to 61.5 units.mg(-)(1)) over 7 days during storage at 20 degrees C. However, its activity changed little during storage at lower temperatures. These results indicate that the reduction during storage of the quality of L. edodes as a functional food is accompanied by the decrease of lentinan, and by browning, and that exo-glucanase plays an important role in the decrease of lentinan content.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214552/
The cultivation of shiitake dates way back to 1100 A.D. during the rule of Sung dynasty which is replaced by more modern and efficient sawdust substrate log cultures lately. Shiitake mushroom extract can be isolated in various forms such as freeze dried, oil, and ethyl acetate extracts. Various biologically active compounds such as erythritol, copalic acid, adenosine, carvacrol, and many more are responsible for this mushroom's antimicrobial activity. Anticariogenicity can be attributed to the induction of the detachment of cariogenic microorganisms from hydroxyapatite, changes in cell surface hydrophobicity, bactericidal activity, and disruption of signal transduction in Streptococcus mutans as proved through various in vivo and in vitro studies. Apart from these benefits, it has tremendous potential to be used as an antioxidant, anticancer, antigingivitis, antifungal, and antiviral agent.


























































2 comments:

  1. Check this out

    https://bengreenfieldfitness.com/transcripts/transcript-how-to-use-wholetones-music/

    Check this out michael tyrell created a whole tones cd collection that talks about the notes and different frequency and Hertz that can target specific organs and give feelings of peace and other spiritual experiences. He said a friend of his who owned a supp company grew his plants while this music played and it created an amazing yield and bioavailabitliy of the nutrients. Amazing stuff!

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    Replies
    1. skyler thanks! I thought maybe it was about "PrimaSounds" - this https://www.youtube.com/watch?v=T7COc76XJx4&list=PLJC76L-74m-Axtt6fbjmnQF7WOX4WV-oG
      7 "frequencies" - I think he's just promoting the supposed Solfeggio hertz tunings. If people want to believe in it - go for it. I'm not gonna try to stop people. haha.

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