I was talking literally for hours with my aunt yesterday and I mentioned the natural opiate system - talking about runner's high and something else. And she asked me if that opiate system was from the pituitary gland. I had mentioned the pineal gland earlier - how I could feel it as magnetic bliss. So I think she meant the pineal gland.
It is suggested that interactions between the pineal gland and opioid
peptides may be involved in the regulation of rhythmic behaviors
Fish can serve as a means to study this...
OK I'll read that article.
The presence and actions of opioid receptors in bovine pineal gland
Article· Literature Review (PDF Available) in Journal of Pineal Research 13(3):124-32 · November 1992
The results of these studies indicate the existence of pineal opioid
receptors, which play a pivotal role in the synthesis of melatonin and
its action in synchronizing pineal events.
and so this "opiate system" can also get damaged...
Abnormal states (i.e. drug abuse) could result in altered pineal
activity, then in rhythmically altered functions of cerebral opiates
and/or monoamine neurotransmitters. This may led to the development of a
“reward - urge for drug rhythm” resulting in craving, ending in
addiction.
1Biology, GSK Verona, Italy
In normal conditions melatonin might be acting as a cerebral
"pacemaker", sensitive to endogenous as well as exogenous stimuli in the
attempt to maintain an equilibrate circadian interaction between the
cerebral activities of endogenous aminergic and opiates systems
(probably via a circadian mechanism). However, abnormal states (i.e.
drug intake, abuse, addiction) could result in chronically altered
pineal functions, resulting in rhythmically higher synthesis and release
of melatonin (increased turnover). This could be either an original
effect of drug intake or subsequent to modified activity of aminergic
(dopaminergic, serotonergic) and/or opioidergic systems following drug
abuse
32, 33.
This change in the pineal functions
could result in a rhythmically
abnormal change in the functions of cerebral opiates (which should be
reduced) and/or monoamine neurotransmitters, i.e. altered functions of
DA in the nAcc (with a rhythmically higher increase and decrease of DA
activity) and/or opposite modification of serotonergic functions, which
could end in the development of a "circadian" state of reward - urge for
drug (craving) resulting in addiction (see the resulting Figure 1).
Their research on the pineal gland have revealed a genetic connection between left-right asymmetry and day-night cycles.
wow!! Fascinating!
https://medium.com/@humanoriginproject/the-entire-function-of-the-pineal-gland-9b53d6a54019
Today, evidence suggests the pineal gland is the master conductor of the physiology of the brain and body.
As the master conductor of the body, the pineal gland is responsible for hormone release from the pituitary gland.
pineal gland asymmetry resonance!
maintenance of asymmetry between specific odor-perception neurons in worms is important for odor discrimination [16]; and loss of asymmetry in parts of the fly brain diminish long-term memory [17].To
take the question further: Why is coordinated asymmetry in a population
important? How do the behaviors regulated by the pineal complex and the
habenular nuclei benefit from population-level coordination of
laterality?
wow - fascinating!!! Yes indeed.
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