Searching the Latin name Glechoma hederacea L. for Ground Ivy aka Creeping Charlie into googlescholar reveals a lot of research in just the past four years on its medicinal commercial food properties as a "phytotherapeutic" : https://www.sciencedirect.com/science/article/abs/pii/S0308814625011586
including the increased demand for dark chocolate and the inclusion of polyphenolic compounds. Ground ivy [Creeping Charlie] (Glechoma hederacea L.) was selected as a plant source of polyphenolic compounds.
Development of new chocolate formulations by incorporating spray-dried and liposomal encapsulates of ground ivy (Glechoma hederacea L.) [Creeping Charlie] polyphenolic extract
Herbal aroma, originating from incorporated ground ivy [Creeping Charlie] extract, was not perceived by the panellist as
the highest score was 3.1 (sample CP_B).... Ground ivy extract and investigated honey samples were successfully used in combination as a filler
for the chocolate pralines, as all the formulated pralines were sensory evaluated as highly acceptable. Ground ivy [Creeping Charlie] extract served successfully as a natural source of bioactive compounds,
Development, bioactive and sensory analysis of the honey-filled chocolate pralines infused with ground ivy (Glechoma hederacea L.) [Creeping Charlie] extract
https://www.researchgate.net/publication/376974493_Development_bioactive_and_sensory_analysis_of_the_honey-filled_chocolate_pralines_infused_with_ground_ivy_Glechoma_hederacea_L_extractCorresponding author: drazenka.komes@pbf.unizg.hr
Croatia
2 handfuls of fresh creeping charlie
Functional food products can combine health benefits with enhanced sensory properties. Microparticles containing ground ivy [Creeping Charlie]
extract were incorporated into candies....Ground ivy extract was also worked into the filling of chocolate pralines,...G. hederacea [Creeping Charlie] has been a subject of numerous patents–a SciFinder search identified 191 patent records....
Glechoma hederacea L., commonly known as ground ivy, which belongs to the Lamiaceae family. Ground ivy is an aro-
matic plant native to Europe and to western and northern Asia [5–8]. The medicinal properties of ground ivy have been recognized
in Europe since ancient times, where it was utilized to treat liver and spleen ailments. Traditionally, it is still used to treat gastroin-
testinal disorders, liver and bile diseases, diabetes, various inflammatory conditions (including respiratory issues
The European literature, particularly from Poland and Germany, indicates it is typically harvested during flowering and dried in the
shade under warm, well-ventilated conditions at 35–40 °C. A decoction is prepared by putting 1 (1½) tablespoon of plant material
in 1–1½ (1½–2) cups of warm water, boiling the mixture covered for 5 minutes, and then letting it sit for 10 minutes before strain-
ing [10, 12, 72]. A decoction of 1 tablespoon G. hederacea herb with ¼ liter of water, or equal parts water and vinegar, may be ap-
plied in compresses to relieve rheumatic and arthritic pain. A tincture, which shares the same medicinal properties as the decoc-
tion, can be created by infusing ethanol with ground ivy juice in a 1 : 1 ratio for two weeks [9, 58, 62]. A daily serving of infusion is
made by pouring 1(− 2) cups of boiling water on 1(− 1½) tablespoon of ground herb [11, 39, 58]. Ground ivy [Creeping Charlie] juice is prepared
from fresh herb harvested in spring using a meat grinder. Such juice is drunk in the morning and in the evening [60].
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Ground ivy [Creeping Charlie] has been used in cooking and brewing for centuries due to its strong aroma. Before being replaced by hops (Humulus
lupulus L.), it was used to flavor beer [22, 24]. It has also been used as a condiment and addition to soups, stews, and restorative bul-
lion in the Trás-os-Montes region in Portugal [29]. It has served as a tea in Austria [59], as well as in Switzerland, next to its use in al-
coholic beverages and as a spice [73]. In Czech Republic, it has been added to soups, vegetable dishes, and scrambled eggs
[36]. In Slovakia, it has been used as a condiment and an addition to sauces, soups, roux, and cooked barley [74]. In Poland, it has
been utilized in broths and potato soup and as a flavoring herb in place of parsley [75]. In old English recipes, leaves were an ingre-
dient of jams, soups, oatmeal, and vegetable dishes [24]. Gastronomic use of aerial parts was also recorded in northeastern Italy
[67].
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In vitro studies utilizing a range of cell-free systems, as well as human and animal cell lines, have demonstrated various
biological activities, including antioxidant, anticancer, cytotoxic, genoprotective/genotoxic, antimutagenic/mutagenic, anti-in-
flammatory, antibacterial, neuroprotective, antiepileptic, spasmolytic, melanogenesis-modulating, anti-osteoporotic, and he-
mostatis effects. In contrast, in vivo studies in animal models remain limited and have primarily focused on anticancer and cyto-
toxic activities (one study in a mouse model), hepatoprotective effects in liver diseases (two studies in rat and mouse models), anti-
inflammatory activity (one study in rat model), and antibacterial potential (one study in rat model).
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Although there is a lack of precise toxicological data, G. hederacea products are considered relatively safe. This statement is sup-
ported by the fact that they have been used in traditional medicine for many years, with no adverse effects reported.
Glechoma hederacea var. longituba [Creeping Charlie] is a herbaceous plant from the Lamiaceae family, used in herbal medicine.... The high TPC [Total Phenolic Content] values correlate with high antioxidant properties, as well as antimicrobial (excluding filamentous fungi) and antibiofilm activity (the prevention of biofilm formation).
...the abundance of samples in terms of insoluble dietary fibre, protein, calcium and potassium, while rutin, chlorogenic, cryptochlorogenic, caffeic and rosmarinic acid were the most dominant phenolic compounds....Glechoma hederacea L., known as ground ivy, is one of them, and although it has been used for generations in folk medicine, up until today, there is a lack of scientifically based information about its biological activity, nutritive and bioactive composition. Among them, antioxidant activity—higher than that of vitamin C and Trolox—as well as the antiinflammatory and antimutagenic potential of ground ivy, due to the presence of phenolic compounds, have been reported [6,7]. The most common phenolic compounds in plants are flavonoids and phenolic acids, from which antioxidant properties arise from hydroxyl groups in the ring structure and their arrangements [8]....
Ground ivy [Creeping Charlie] has been used for generations as a traditional herbal preparation—dried leaves in infusions to treat respiratory diseases such as asthma, bronchitis, colds, coughs and sore throats, drinks made from the fresh plant for digestive problems and decoctions externally to treat skin irritations. In addition, ground ivy has also been used as a diuretic and stimulant, as well as for the treatment of headaches, arthritis, scurvy, jaundice, menstrual or puerperal disorders and mental disorders such as hypochondria and monomania. The aforementioned biological activities are associated with the antioxidant capacity of ground ivy due to the presence of various bioactive compounds, especially polyphenolic compounds [7]. The most represented phenolic compounds in ground ivy are phenolic acids such as rosmarinic, protocatechuic, caffeic, chlorogenic, cryptochlorogenic and ferulic acids, while among the flavonoids, the presence of rutin, isoquercetin, genistin, genistein and daidzin has been reported [8–10]
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It is obvious that the species G.hederacea [Creeping Charlie] has excellent antimicrobial properties against E. coli, B. subtilis and C. parapsilosis, and can also be used as a potential source of compounds with antibacterial activity,
https://www.beilstein-journals.org/bjoc/articles/18/58/?T=y
[Creeping Charlie] contains phytochemicals such as monoterpenoids, sesquiterpene lactones, lignans, flavonoids, and phenolic compounds that show anti-inflammatory, cytotoxic, and/or cytoprotective effects [3-7]. However, bioactive terpenoids of G. hederacea var. longituba [Creeping Charlie] with antineurodegenerative effects remain largely unknown. In this study, nine terpenoids (1–9) including five new compounds (1–5) were iso-
lated and characterized from G. hederacea var. longituba (Figure 1).
To find potential antineuroinflammatory, neurotrophic, and cytotoxic secondary metabolites from G. hederacea var. longituba [Creeping Charlie], the isolated compounds (1–9) were evaluated for these biological activities....
Compounds 2 and 5–7 caused significantly reduced NO levels. Compound 5 exhibited a neurotrophic effect. Interestingly, compounds 4 and 5 showed differences in antineuroinflammatory activity and neurotrophic effect according to the C-2' functional group of the glucopyranosyl
group. Compounds 7 and 9 showed selective cytotoxic activities against human cancer cell lines. This study suggests that the
bioactive tepenoids (2, 5–7, and 9) from G. hederacea var. longituba [Creeping Charlie] would be potential new drug candidates
Terpenoids are ten-carbon compounds comprising two five-carbon isoprene unit derivatives that provide crucial roles in plant defense, growth and development, and responses to environmental changes. Additionally, terpenoids have many medicinal properties, further indicating the importance of terpenoids (Jin et al. 2025).
Glechoma hederacea (Ground ivy) [Creeping Charlie] is a weedy plant belonging to the mint family, Lamiaceae
which is known for its wide spectrum of volatile terpenoid compounds (Radulović, Niko, et al., 2010). It was brought to North America from Europe during early settlement where it has now become naturalized (Scholler & J. Böllmann, 2004).
Ground ivy [Creeping Charlie] is one of the medicinal and aromatic plants (MAPs) that is valued not only for its therapeutic potential, but is also widely used in the food industry, particularly in herbal teas and as a spice.
while studies on such modern formulations are in progress, the marketed product which is available to consumers is still the dried plant, supplied as a single-ingredient loose herb (Glechomae hederaceae herba).
Rosmarinic acid, rutoside, or chlorogenic acid can indicate Glechomae herba [Creeping Charlie] quality.
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