Thursday, May 16, 2024

Tauopathy vs the Dao: The Ancient (over 500 million years ago) Microtubule-Myelin connection as secret of Cambrian Explosion

 https://pubmed.ncbi.nlm.nih.gov/31522889/

 Microtubules are critical for the extension of oligodendrocyte processes and myelin deposition, yet our knowledge of their microtubule biogenesis is limited. In this issue of Cell, Fu et al. (2019) identify an oligodendrocyte-enriched microtubule regulator that promotes microtubule growth from Golgi outposts and controls myelin sheath elongation, linking microtubule cytoarchitecture and myelination in the CNS.

Microtubules, Myelin Sheaths, and Altered Behavior 

 Tubulin Cytoskeleton in Neurodegenerative Diseases–not Only Primary Tubulinopathies

Searching for effective therapies for neurodegenerative diseases is undoubtedly necessary and urgent. This is, on the other hand, an extremely difficult task due to complex pathomechanisms of these diseases, their variabilities and different symptoms observed in patients. Moreover, ability of neurons to regenerate is extremely limited. Unfortunately, vast majority (if not all) of neurodegenerative diseases remain incurable (Pierzynowska et al. 2020).

Cytoskeleton with Special Emphasis on Microtubules

Cytoskeleton is a network of interlining filamentous proteins occurring in cytoplasm. It was assumed that it occurs solely in eukaryotic proteins, however, some 30 years ago, protein motifs homologous to actin (Bork et al. 1992) and both subunits of tubulin (α-tubulin and β-tubulin) (de Boer et al. 1992; RayChaudhuri and Park 1992; Mukherjee et al. 1993; Yutin and Koonin 2012) were discovered in bacteria and archea. Nevertheless, it is unlikely that the cytoskeleton of eukaryotic cells derives from prokaryotes, as detailed analyses indicated significant functional differences between components of cytoskeletal proteins occurring in eukaryotes and their bacterial structural analogs (Vesteg and Krajcovic 2008).

 dysfunctions of mitochondria, leading to production of reactive oxygen species in cerebral endothelial cells. This can activate vascular inflammation that stimulates microglia and astrocytes, triggering the inflammatory cascade. As the inflammation becomes widespread, the blood–brain-barrier function is impaired, leading to neuroinflammation and further to neurodegeneration. In this light, it is important to note that recent review of medical data and analyses and experimental results led to the conclusion that the primary deleterious effects of P-tau are related to mitochondrial dysfunctions (Epremyan et al. 2022).

  tau protein predominates in axons... This protein is normally associated with microtubules and promotes their assembly, as well as stabilizes these structures (physiological roles of tau have been reviewed recently by Liang et al. 2022). Due to alternative splicing of mRNA of the tau-encoding gene (the MAPT gene), there are 6 isoforms of the tau protein which differ in the length, ranging from 352 to 441 amino acid residues. These isoforms are classified as 3R (including 0N3R, 1N3R, and 2N3R isoforms) and 4R (including 0N4R, 1N4R, and 2N4R isoforms) groups

 Definitely, P-tau contributes significantly to microtubule breakdown, while disrupted tubulin homeostasis facilitates tauopathy

Earth At Risk & Blusink: Sir David A. King's latest on the deep ocean phytoplankton bloom carbon sequestration plan

 Sir David King 'The Climate Expert': High Net Purpose

Mimicking the Whale Poo - using rice hulls from Goa mixed with volcanic ash and lignin as glue....

 Lignin is the main by-product of paper pulping processes and is typically burned as fuel. Being the natural glue in plants and having a phenolic nature makes lignins an attractive replacement for wood adhesives.

 Volans Book Club - Sir David King in conversation with Louise

 

 Earth at risk: An urgent call to end the age of destruction and forge a just and sustainable future

 https://www.blusink.com/

 https://rethinkingremovals.org/

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

AI General Intelligence originates from Charles Spearman General Intelligence Eugenics Tests

 https://monthlyreview.org/2022/09/01/intelligence-under-racial-capitalism-from-eugenics-to-standardized-testing-and-online-learning/

Reimagining A.I. | John Wild 

Wednesday, May 15, 2024

Psychiatry proven to be mass mind control by James Bovard

 Psychiatry is ruining more lives than ever before. The New York Times recently showcased psychiatric “prevalence inflation” – a vast increase in reported mental illness among teenagers who are encouraged to view normal feelings as grave maladies requiring intervention.

Oxford University psychologist Lucy Foulkes observed that school programs are “creating this message that teenagers are vulnerable, they’re likely to have problems, and the solution is to outsource them to a professional.”  In an academic analysis published last year, Foulkes explained that “awareness efforts” spur young people “to interpret and report milder forms of distress as mental health problems.” Filing such complaints “leads some individuals to experience a genuine increase in symptoms, because labeling distress as a mental health problem can affect an individual’s self-concept and behavior in a way that is ultimately self-fulfilling.”

Like a New Yorker cartoon from the 1950s, psychiatric diagnoses have become status symbols, propelled by snake oil “social emotional learning” programs.  University of Southern California clinical psychologist Darby Saxbe warns that mental illness labels have “become an identity marker that makes people feel special and unique. That’s a big problem because this modern idea that anxiety is an identity gives people a fixed mindset, telling them this is who they are and will be in the future.”  Psychiatric labels can become a ball-and-chain that people drag behind them.  The New York Times found that many young people were left worse off thanks to “mental health interventions.” Endless classroom presentations on mental health spur “co-rumination” – excessively talking about one’s problems – which evokes memories of first dates from hell.

Hungarian-American psychiatrist Thomas Szasz warned in the last century, “Psychiatrists manufacture mental diagnoses the way the Vatican manufactures saints.” But protests by Szasz and other dissident shrinks did nothing to prevent a sham stampede.

The American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders (DSM) now lists more than 300 mental illnesses, five times as many as it specified in the 1960s. Dr. Allen Frances, writing in Psychology Today, warned that the latest DSM contained “many changes that seem clearly unsafe and scientifically unsound” and is “likely to lead to massive over-diagnosis and harmful over-medication.”  After the DSM redefined autism in the 1990s, the autism rate “quickly multiplied almost 100 fold.” Thanks to another DSM redefinition, the “number of American children and adolescents treated for bipolar disorder increased 40-fold” between 1993 and 2004, the New York Times reported. Psychiatrist Laurent Mottron complained in 2023 that the latest version of the DSM “is full of vague and trivial definitions and ambiguous language that ensures more people fall into various, abnormal categories.”

The DSM provides a road map for federal law.  The Americans with Disabilities Act (ADA) compels schools and universities to provide “reasonable accommodation” to students who claim to have a disability, physical or mental. Even before the pandemic, up to 25% of students at top colleges were “classified as disabled, largely because of mental-health issues such as depression or anxiety, entitling them to a widening array of special accommodations like longer time to take exams,” the Wall Street Journal reported in 2018. Similar string-pulling occurs for the rigorous entrance exams for New York City’s elite high schools, where “white students… are 10 times as likely as Asian students to have a [disability] designation that allows extra time,” the New York Times reported.

Between 2008 and 2019, the number of undergraduate students diagnosed with anxiety increased by 134%, 106% for depression, 57% for bipolar disorder, 72% for ADHD, 67% for schizophrenia, and 100% for anorexia, according to the National College Health Assessment. Students’ struggles skyrocketed after COVID shutdowns. A Boston University analysis of students on almost 400 campuses in 2022 found that “60% of the respondents met the qualifying criteria for ‘one or more mental health problems, a nearly 50% increase from 2013.’”  But awarding endless psychiatric Purple Hearts will do nothing to help college graduates adjust to the challenges of life beyond the classroom.

I recognized that the DSM was becoming unhinged after attending the 1986 annual meeting of the American Psychiatric Association in Washington. Here are some riffs from a Detroit News piece I wrote at that time:

The APA served attendees a batch of freshly-ordained mental illnesses, including  “premenstrual dysphoric disorder.” The APA says symptoms of this “mental illness” include “irritability,” “marked fatigue,” and “negative evaluation of self.” According to the APA’s definition, a third of all women go crazy once a month.

The second newly ordained mental illness is “self-defeating personality type,” previously known as common or garden-variety masochism. The symptoms for this grade disorder include, “complaints, directly or indirectly, about being unappreciated,” “repeatedly turns down opportunities for pleasure,” and “remains in relationships in which others… take advantage of him or her.” Bring on the Valium!

The third “discovery” was guaranteed to raise the APA’s popularity with trial lawyers. The APA tentatively decided that anyone who persistently fantasizes about or actively forces a non-consenting person to have sex suffers from “paraphilic rapism.” In other words, a person would have to be nuts to rape somebody. As one protester at the APA’s meeting declared, “Sexual assault is a crime – not a mental disorder.” The Committee of Women of the APA said the new category would “provide an instant insanity plea for anyone charged with rape.”

The redefinition of rape epitomizes psychiatry’s view of crime: no one is responsible for anything and psychiatrists should have supervision over everything. The big hero at the APA’s convention was Jack Hinckley, father of John Hinckley, who announced he was launching a campaign to increase public support for psychiatry. (His son was seeing a psychiatrist before he shot President Reagan, but APA members would rather not talk about that.) The psychiatrist introducing Hinckley, Sr., spoke movingly about the “tragedy that struck the Hinckley family” – with no thought of a nation that was almost robbed of its elected leader.

The APA’s new mental illnesses will provide shrinks with lucrative new court “expert witness” opportunities. One woman already successfully used premenstrual syndrome as an “insanity” defense for murdering her husband, and PMS is now being used as a defense in child abuse cases. This is progress?

If shrinks only cleaned out people’s wallets, then they would be no more harmful than your average politician. But psychiatrists nowadays routinely rely on mind-numbering drugs and mind-shattering electric shock treatments. Some mental patients are developing Parkinson’s disease symptoms as a result of years of heavy medication. Electric shock “therapy” – aside from being a terrifying experience – sometimes causes permanent memory loss, thus making it harder for a patient to handle reality.

We have new mental illnesses not because of new breakthroughs in understanding the mind, but because psychiatrists want more money and more power over the rest of us. Shrinks generally have a poor batting average for curing known mental problems – but that has not stopped them from creating new “illnesses” that supposedly they alone can treat.  But a con artist with an M.D. is still a con artist.

***

My carping did nothing to slow the hucksters.  In 2019, the American Psychological Association officially designated traditional masculinity as a de facto mental illness.  Their new guidelines specifically state that “stoicism” and other traits are “on the whole, harmful.”  Did that make Marcus Aurelius spin in his grave?  Apparently, instead of toughing out challenges, people are supposed to spend their lives whimpering to shrinks and getting appropriately drugged.  But the Food and Drug Administration is a shill for Big Pharma and is unlikely to expose or admit the long-term harm from drugs that can partially numb minds.

Psychiatrists have helped some individuals better understand themselves and deal more deftly with everyday reality.  But bogus mental illnesses have turned millions of healthy Americans into “mental patients,” according to Dr. Allen Frances.  That debacle explains why Thomas Szasz crusaded against the “therapeutic state” and the “medicalization of everyday life.”

But this peril also profoundly endangers freedom.   The profusion of new diagnostic labels encourages people to view themselves as psychologically fragile. Actually, the Americans with Disabilities Act tacitly rewards people who demand “reasonable accommodations” because they are depressed or anxious.  Those incentives create a downward politico-psychological spiral.  Besides, if you’re reading this website, you’re at risk of being designated – i.e., found guilty – of DSM category 313.81, Oppositional Defiant Disorder. One tell-tale trait of that mental illness: “Often argues with authority figures.”  Would my sarcastic tweets suffice to convict me on that charge?

Therapists are hollowing out the American character, generation by generation. What do they  offer in lieu of the stoicism they deride? Unfortunately, there is no DSM category for people suffering from a “Missing Bullshit Alarm.”  Maximizing the number of people labeled as psychologically fragile or damaged becomes an entitlement program for demagogues riding to the rescue.  A century ago, H.L. Mencken observed,  “The whole aim of practical politics is to keep the populace alarmed and hence, clamorous to be led to safety—by menacing it with an endless series of hobgoblins, all of them imaginary.”  And the more panicky people become, the more gullible they will be.

***

An earlier version of this piece was published by the Libertarian Institute. 

James Bovard is the author of Attention Deficit Democracy, The Bush Betrayal, and Terrorism and Tyranny. His latest book is Last Rights: the Death of American Liberty. Bovard is on the USA Today Board of Contributors. He is on Twitter at @jimbovard. His website is at www.jimbovard.com

Sunday, May 12, 2024

Nahua indigenous people spread pederasty from Pacific region of southern Mexico to the Pacific region of El Salvador (Pipils)

 

 Sigal, P. (2005). The Cuiloni, the Patlache, and the Abominable Sin: Homosexualities in Early Colonial Nahua Society. Hispanic American Historical Review, 85(4), 555–594.

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 https://pdf.usaid.gov/pdf_docs/pnabi651.pdf

 

 

 

 

 

 

 

 

 

 The Politicization of Pederasty among the Colonial Yucatecan Maya

Journal of the History of Sexuality
Vol. 8, No. 1 (Jul., 1997), pp. 1-24 (24 pages)
Published By: University of Texas Press

 

 

 

 Sigal, P. (2002). Gender, Male Homosexuality, and Power in Colonial Yucatán. Latin American Perspectives, 29(2), 24–40.