Friday, March 20, 2026

Why Exercise exorcises fear! Endocannibinoids decrease activation GABA in the amygdala

 Wow that also explains why exercise gets rid of fear because exercise activates your endocannibinoids!

"endocannibinoids] act like traffic cops to control the levels and activity of most of the other neurotransmitters."

attenuated glutamatergic excitation from the basolateral amygdala, which results in a decreased activation of GABAergic neurons in the central amygdala that project to the midbrain and other brainstem nuclei. These results point to a supposed bimodal control of fear expression by cannabinoid signaling.... Under stressful circumstances, the glutamatergic tone increases, producing an imbalance between excitatory and inhibitory transmission. To compensate for this glutamatergic overexcitation, an adaptive compensatory mechanism is activated by CB 1 R downregulation in GABAergic terminals.... the endocannabinoid system is crucial for appropriate fear extinction.


fascinating!!
repeated THC modified dopamine b-hydroxylase activity in rodent serum, a measure of sympathetic system activation. This effect was different depending on the basal status of exposed subjects revealing a complex modulatory role of the endocannabinoid system: THC alleviated sympathetic activation in naive mice but potentiated this response in rodents subjected to immobilization stress. 

 

 

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