Problems with the proper establishment of asymmetry and polarity during cell division can give rise to cancer and neurodevelopmental disorders, as well as to also accelerate cellular aging.
Interestingly, the microtubule organizing centers that orchestrate the formation of the mitotic spindle have been described among the cellular structures that can be differentially allocated during asymmetric cell divisions. This mini-review focuses on recent research from our group and others uncovering a role for the non-random distribution of the spindle-associated microtubule organizing centers in the differential distribution of aging factors during asymmetric mitoses and therefore in the maintenance of the replicative lifespan of the cells.
https://sci-hub.se/10.1038/s41556-019-0364-8
So this is from a year earlier than that first quote.
the level of the microtubule-organizing centres (MTOCs),
Remarkably, the reasons behind the conserved asymmetry in
MTOC distribution are unclear.
The REASON is because reality itself is organized by asymmetric time as the Law of Phase Harmony!!
The differential inheritance of spindle-associated MTOCs duringOK let's go to the paper for that first quote - a year later. Same scientists.
cell division is a fascinating evolutionarily conserved phenomenon.
The asymmetric distribution of MTOCs was later
found to be an evolutionarily conserved process that can be
also observed during the division of many stem cells from
different organisms ranging from Drosophila to humans.
So Western science constantly bombards people with the Symmetry or symmetric math brainwashing from the Golden Ratio foundation of the Greek Miracle. And so a recent Golden Ratio paper makes this incorrect claim that I just disproved with the above quotes....
https://sci-hub.se/10.1016/j.pbiomolbio.2018.12.008
Oops we just showed the opposite! It is non-random asymmetry that drives life and makes life possible.
tedX vid - is understated: Why are human bodies asymmetrical? - Leo Q. Wan
Micropatterned mammalian cells exhibit phenotype-specific left-right asymmetry
critical importance to normal development. Changes in orientation of the LR axis due to
genetic or environmental factors can lead to malformations and disease. While the LR …
Cellular chirality arising from the self-organization of the actin cytoskeleton
embryos remain obscure. Here, the development of a chiral pattern of actomyosin was
revealed by studying actin cytoskeleton self-organization in cells with isotropic circular …
aka MTOCs
Disruption of microtubules by nocodazole was confirmed by anti-α-tubulin immunofluorescence staining. Actin was visualized with phalloidin staining. The radial and chiral patterns of the actin cytoskeleton organization in cells with an intact microtubule system and in cells lacking microtubules are shown.
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