https://pmc.ncbi.nlm.nih.gov/articles/PMC5011233/
OK based on that study I just ordered eight pounds of organic Erythritol!!
I am finishing off my Xylitol - it has done wonders for my teeth - keeps them squeaky clean!
I'll be curious to see what the Erythritol does!
OH dang - that study is 10 years old!?
https://www.tandfonline.com/doi/pdf/10.1080/20002297.2025.2526069
Here's a new one.
In the erythritol group, the lactate concentration significantly decreased com-Organic erythritol is produced through the controlled microbial fermentation of organic plant-derived glucose using natural yeasts or fungi
pared to that of the control group, whereas the pH did not significantly change. In addition, when nitrate was added in combination with xylitol or sorbitol, neither the pH nor lactate concentration significantly changed compared to those of the control group
(Figure 6a,b)....The present study suggests that the combined addition of nitrate and erythritol significantly increased the relative abundance of H. parainfluenzae and
N. subflava, which are nitrate-reducing bacteria...Notably, the combined addition of nitrate
and either xylitol or sorbitol had no significant effect on the relative abundances of H. parainfluenzae, N. subflava, and S. oralis, nor the diversity of the microbial community.... These results suggest that the combined addition of nitrate and erythritol may
promote an oral cavity environment that is less conducive to the development of dental caries.
https://link.springer.com/content/pdf/10.1186/s12939-024-02279-0.pdf
Upon ingestion, erythritol is rapidly absorbed in
the small intestine, with most excreted unchanged in the urine and a small
portion metabolized to erythronate.4 The absorption rate is dose-
dependent, as demonstrated in a recent trial where higher doses (50 g) re-
sulted in slower absorption compared with lower doses (10 g, 25 g),
suggesting a saturable process.
While consumption
of erythritol has no impact on plasma glucose and insulin levels, xylitol leads
to a small increase.
More recent studies have repeatedly demonstrated that acute erythritol
and xylitol consumption—despite their lack in calories—trigger gastro-
intestinal satiation hormones (incretins) release (namely cholecystokinin,
glucagon-like peptide-1, and peptide tyrosine tyrosine), and erythritol
has also been shown to lower concentrations of the hunger hormone
ghrelin.
Mendelian randomisation analyses did not find evidence for a causal
association between circulating erythritol and coronary artery disease, dia-
betes, fasting glucose, eGFR, or chronic kidney disease, nor was any evi-
dence found that the evaluated cardiometabolic and anthropometric
traits significantly influenced erythritol concentration. Rather, Mendelian
randomisation indicated erythritol may decrease BMI
While a significant proportion of xylitol enters the colon, erythritol is
mostly absorbed in the small intestine.4 Moreover, erythritol, which is
only minimally available to the colon, appears non-fermentable, as shown
in studies with fresh human faecal microbiota.56 Overall, xylitol appears
to have prebiotic effects, whereas erythritol likely has no impact on the
gut microbiota.
This study found that erythritol consumption acutely im-
proves small vessel endothelial function (fingertip peripheral arterial tono-
metry), and chronic treatment reduced central aortic stiffness (decreased
central pulse pressure).59
In humans with or without obesity, both acute erythritol and xylitol ingestion also delays gastric emptying
The consumption of erythritol and xylitol stimulates the release of
gastrointestinal satiation hormones while the impact on blood glucose
and insulin concentrations remains minimal. These effects are desirable
in the context of metabolic and CV health.
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