Monday, May 16, 2022

Salvia Divinorum shuts down the Claustrum! The "wheel" of light emerges when the dopamine circuit is shut down!

 Patrick Smith on Salvia Divinorum and the wheel of life - what I call the "cosmic rainbow vortex."

 https://elixirfield.blogspot.com/2022/04/matthew-manning-endures-despite-james.html

The Claustrum is closely linked to the Nucleus Accumbens that was discovered to be the secret of Michael Manning's psychic spiritual powers

 Claustral neurons expressing dopamine receptors project to frontal cortex and support the acquisition of cocaine and real-time place preference. There is a large body of literature relating to the nucleus accumbens as the central integrator of reward, supporting its role in incentive salience in reinforcement and drug addiction. This raises the question of how our results regarding the role of the claustrum in place preference, and our proposal that the claustrum functions in incentive salience, could relate to the established role of the nucleus accumbens. Although this is largely a topic for future investigation, our perspective is that the functional anatomy of the NAc, with its convergence of dopaminergic, cortical, hippocampal, and amygdalar inputs, and its simple subcortical output, supports its function in reinforcement learning. In contrast, the claustrum exhibits rich reciprocal connectivity with cortex, primarily frontal and association regions, an architecture more amenable to supporting “online” modulation of salience and attention. The claustrum might act to direct attention to reward-related salient cues, promoting the development of a strong association between the reward and its context. The frontal projection of the claustrum has been reported to drive robust feedforward inhibition, dramatically shaping the activity pattern of frontal neurons [40]. Potentially, cocaine-driven allocation of cortical resources increases incentive salience to drug-associated cues by suppressing the activity of frontal cortical resources directed to other, competing objectives. This function might be mediated by dopamine receptors expressed on frontal-projecting claustral neurons, supporting the development of preference for drug-associated contextual cues.

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