Long term Caffeine use Causes Essential Tremors! Striatum D3 Upregulation causes Tremor and Caffee upregulates D3 dopamine in the Striatum!

These results suggest for the first time that upregulated striatal D₃ receptors correlate with TD in non-human primates

Upregulation of dopamine D3, not D2, receptors correlates with tardive dyskinesia in a primate model

 In addition, caffeine-induced increases in D₂/D₃ receptor availability in the ventral striatum were associated with caffeine-induced increases in alertness.

Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain

Aka UpRegulation. Meaning MORE receptors are made on the neurons due to caffeine use.

Am I the first one to discover this connection? I hope not.

I'm watching Walter Lewin, MIT physics Prof - and this is almost 10 years ago - but he's got a tremor!

So I figure he must drink coffee - and I put 2 and 2 together - since I just learned caffeine Upregulates or INCREASES the D3 dopamine receptors in the back of the brain.

I know that the back of the brain controls motor or movement.

Therefore....

And sure enough...

Jan 23, 2019 - Find out more about this disorder that causes uncontrollable shaking and ... be aggravated by emotional stress, fatigue, caffeine or temperature extremes ... causes essential tremor in people without a known genetic mutation.

aggravated or CAUSED?

 About half of essential tremor cases appear to result from a genetic mutation. This form is referred to as familial tremor. It isn't clear what causes essential tremor in people without a known genetic mutation.

 It is well recognized that caffeine and beta-adrenergic drugs are capable of both causing tremors and worsening existing tremors. The severity of the effect may vary according to the amount of caffeine consumed.

Epigenetics is likely cause

it is likely that the disorder occurs as a result of complex genetic factors interacting with various cellular and environmental factors that can result in abnormal function of circuitry involving the cerebello–thalamo–cortical pathway. Genetic analyses have uncovered at least 14 loci and 11 genes that are related to ET, as well as various risk or protective genetic factors. Limitations in ET genetic analyses include inconsistent disease definition, small sample size, varied ethnic backgrounds and many other factors that may contribute to paucity of relevant genetic data in ET.