https://www.researchgate.net/publication/248425221_Advances_in_lentinan_Isolation_structure_chain_conformation_and_bioactivities
https://pdfs.semanticscholar.org/d30b/88490eefdc8e5b59cdafac00371d3d4698e1.pdf
So it is "heat stable" -
and
Encyclopedia of Dietary Supplements - Page 721 - Google Books Result
Paul M. Coates, Joseph M. Betz, Marc R. Blackman - 2010 - Health & Fitness
Dried shiitake mushrooms are rich in carbohydrates and protein. ... or fruiting bodies because drying concentrates the lentinan and other active principles.
J Am Coll Nutr. 2015;34(6):478-87. doi: 10.1080/07315724.2014.950391. Epub 2015 Apr 11.
Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults.
Dai X1, Stanilka JM1, Rowe CA1, Esteves EA2, Nieves C Jr1, Spaiser SJ1, Christman MC3, Langkamp-Henken B1, Percival SS1.
The influence of Lentinus edodes (Shiitake mushroom) preparations on bacteriological and morphological aspects of the small intestine in piglets.Shiitake mushroom dermatitis is a cutaneous reaction caused by the consumption of raw or undercooked shiitake mushrooms. Symptoms include linear erythematous eruptions with papules, papulovesicles or plaques, and severe pruritus. It is likely caused by lentinan, a heat-inactivated beta-glucan polysaccharide. Cases were initially reported in Japan but have now been documented in other Asian countries, North America, South America, and Europe, as this mushroom is now cultivated and consumed worldwide. Shiitake mushroom dermatitis may result from mushroom ingestion or from handling, which can result in an allergic contact dermatitis.
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